NF-kappa-B inhibitor beta (NFKBIB) (Middle Region) Peptide
NFKBIB
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN980674
Aperçu rapide pour NF-kappa-B inhibitor beta (NFKBIB) (Middle Region) Peptide (ABIN980674)
Antigène
NFKBIB
(NF-kappa-B inhibitor beta (NFKBIB))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-NFKBIB antibody (Catalog #: ARP34381_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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Sujet
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Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c
Alias Symbols: IKBB, TRIP9
Protein Interaction Partner: IKBKB,MCC,RELA,RELA,BTRC,CD3EAP,CHUK,CUL1,IKBKB,IKBKG,KPNA2,LRPPRC,MCC,MTIF2,NFKB1,NFKB2,NFKBIA,NGFR,NKIRAS1,NKIRAS2,PDCD2,POLR1A,POLR1B,POLR1C,POLR1D,POLR1E,POLR2H,POLR2L,RASAL2,REL,RELA,RXRA,SKP1,BTRC,CHUK,IKBKB,NKIRAS1,REL,RELA,RXRA,Thrb
Protein Size: 356 -
Poids moléculaire
- 38 kDa
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ID gène
- 4793
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NCBI Accession
- NM_002503, NP_002494
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UniProt
- Q15653
Antigène
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